Business Systems Senior Manager, Procure to Pay

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide. Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients. The Opportunity: Revolution Medicines is seeking a Business Systems Senior Manager, Procure to Pay to join the Information Sciences (IS) Enterprise Applications team. This role will serve as the primary technology partner and hands-on system owner for Coupa, Omnea, and related applications supporting Procurement and Accounts Payable (AP). The role will own the application roadmap and lifecycle, including administration, enhancements, integrations, reporting, automation, controls, and production support, with a key priority of scaling procurement and invoice processes across global entities, including Europe and Japan/Asia Pacific (JPAC). This individual will partner with Procurement, AP, Finance, Tax, Legal, Compliance, and regional teams to improve the experience from intake through purchasing and invoicing, strengthen data quality, and enable reliable downstream payment and reporting processes. Key responsibilities will include: Own the Coupa and Omnea roadmap, configuration, enhancement backlog, and service delivery; prioritize investments with business partners based on value, risk, and global operating needs. Administer and optimize Coupa supplier onboarding, catalogs and punchouts, requisitions, purchase orders (POs), receiving, approval hierarchies, invoicing, and procurement controls. Partner with AP to improve PO and non-PO invoicing, two- and three-way matching, tolerances, exception resolution, credit notes, duplicate-invoice controls, and invoice approvals; support enterprise resource planning (ERP) posting, reconciliation, and payment-status visibility. Design Omnea intake forms, questionnaires, conditional routing, approvals, notifications, and cross-functional reviews involving Procurement, Legal, Finance, Security, Privacy, and supplier risk. Lead Coupa deployment and ongoing support for Europe and JPAC. Translate local entity, currency, language, tax, invoice, and approval needs into configuration and integrations, including e-invoicing where applicable, in partnership with regional Finance, Tax, AP, and Compliance. Establish reusable country-onboarding standards, regional support coverage, and training; coordinate testing and releases across time zones. Own functional integration design across Omnea, Coupa, ERP, identity, supplier-risk, and contracting platforms. Define data mappings, system-of-record ownership, status synchronization, error handling, monitoring, and reconciliation with integration engineers. Identify and deliver automation using Workato or similar integration platforms, including workflow orchestration, exception routing, and reconciliation; apply reusable patterns, controlled testing, and production monitoring. Leverage artificial intelligence (AI) to simplify procurement and AP processes, reduce manual effort, and improve the user experience while maintaining appropriate data privacy, controls, and human oversight. Build and maintain Coupa reports, dashboards, and scheduled reporting for spend, open POs, commitments, invoice aging and exceptions, approval cycle times, supplier activity, and adoption; validate results with Procurement and Finance. Partner with data engineering and analytics teams t…

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