Manager, Clinical Supply Chain

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us. Centessa Pharmaceuticals, a wholly owned subsidiary of Eli Lilly and Company, is a clinical-stage company developing orexin receptor 2 (OX2R) agonists as a new class of medicines for the treatment of narcolepsy and potentially other sleep-wake disorders. Centessa’s lead investigational candidate – cleminorexton (formerly ORX750) – is being developed for narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia. Centessa's OX2R agonist portfolio includes additional clinical and preclinical-stage assets with potential utility across a broader range of neurological, neurodegenerative, and neuropsychiatric conditions. Headquartered in Boston, Massachusetts, Centessa was recognized as a Great Place to Work® in 2026. Description of Role Centessa is seeking a Manager, Clinical Supply Chain to support end-to-end planning, execution, and maintenance of uninterrupted clinical supply — including investigational product (IP), comparators, and ancillary materials — across assigned clinical programs. This role ensures compliance with GxP requirements, study timelines, and budgets while partnering cross-functionally with Clinical Operations, CMC, Quality, Regulatory, Finance, and external vendors. Reporting to the Senior Director, Clinical Supply Chain, the individual will build strong relationships with internal teams and third-party suppliers to align objectives and support successful trial execution, with particular attention to clinical forecasts, inventory systems, and IRT tools. Key Responsibilities Clinical Supply Planning & Execution Contribute to the development and execution of clinical supply strategies for early- to mid-phase clinical trials (Phase 1–3 as applicable). Manage clinical supply plans, demand forecasts, and inventory strategies — including tracking through Interactive Response Technology (IRT) systems — in alignment with protocol requirements and enrollment projections. Support packaging, labeling, distribution, and resupply activities for investigational products and comparators. Ensure on-time delivery of clinical supplies to depots and clinical sites globally. Vendor & CDMO Management Partner with Quality, Clinical, CMC, and external CDMOs to develop, review, and approve clinical labels, and support CDMO packaging/labeling schedules to ensure supply availability. Interact regularly with third-party providers to manage the logistics and licenses required to ship materials from manufacturing to bulk storage facilities, courier depots, and investigator sites. Collaborate with CMC and QA to facilitate the document transfer required for IP/QP release by CDMOs. Quality & Compliance Support Monitor shelf-life and expiry dating, and coordinate retest/extension activities with the analytical team to ensure continuous supply. Manage the investigation, reporting, and communication of outcomes from temperature excursions and product complaints. Support product recovery activities pending investigation of IP from investigator sites, as needed. Cross-Functional Collaboration & Representation Communicate effectively across functional areas, applying a solid working knowledge of clinical supply chain processes. Author Pharmacy Manuals for clinical studies, as needed. Represent Supply Chain in Clinical and CMC Sub-Team meetings. Basic Qualifications Bachelor's degree in engineering or scienc…

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