Manager, Clinical Supply Chain

When our people share why they joined Rapport and love it here, it comes down to three things: the science, the mission, and the team. At Rapport, we're driven by a passion for developing precision neuromedicines with the potential for fewer side effects, enabling patients and their families to enjoy healthier, more fulfilling lives. And we're doing this with extraordinary science and awesome people (affectionately called Rapptors). Our innovative scientific platform is centered on Receptor Associate Proteins (RAPs). RAPs are a component of neuronal receptor complexes, which play a crucial role in regulating receptor assembly and function. This precision approach has the potential to revolutionize the development of small molecule therapies. We are excited about the potential of our lead program, RAP-219. Our first indication targets focal epilepsy with additional clinical trials in primary generalized tonic-clonic seizures (PGTCS) and bipolar disorder. The strength of Rapport comes from our Rapptors – who are united by our mission to improve patients lives. We bring the heart and hustle to advance our science forward, always staying true to our core values. We hope you're as excited about this opportunity as we are! This role is located in Boston, MA with an onsite requirement of Monday-Wednesday every week. Your impact: Rapport Therapeutics is seeking a detail-oriented and execution-focused Manager, Clinical Supply Chain to support global supply chain operations for late-stage clinical development and commercialization readiness. As the company advances its lead programs through Phase 3 and prepares for potential regulatory submissions, this role will support the execution of reliable, compliant, and scalable supply across global clinical trials. Reporting into Supply Chain leadership within CMC and Product Development, the Manager will support day-to-day global clinical supply planning and execution, vendor coordination, and cross-functional alignment to help ensure uninterrupted supply of investigational materials. This role is ideal for a supply chain professional who enjoys hands-on execution and is comfortable managing detailed operational tasks while partnering closely with CMC, Clinical Operations, Quality, and Regulatory teams. Your day-to-day: Global & Clinical Supply Chain Execution Support global clinical supply planning and execution for Phase 3 trials, including demand forecasting, inventory tracking, production scheduling, and distribution coordination. Help ensure timely, compliant supply of drug substance, drug product, and clinical trial materials to global clinical sites on assigned programs. CMC & Cross-Functional Integration Partner with CMC, Clinical Operations, Regulatory, Quality, and Program Management to align supply plans with manufacturing campaigns, clinical timelines, and regulatory milestones. Support supply chain readiness activities for pivotal trials. Vendor & CDMO Management Support day-to-day relationships with CDMOs, packaging and labeling vendors, and logistics providers. Assist with contract execution, performance monitoring, issue resolution, and continuous improvement initiatives across external partners. Supply Planning, Systems & Analytics Support clinical demand forecasting, inventory visibility, and supply reconciliation processes. Use supply chain systems, planning tools, and dashboards to support data-driven decision-making and scenario planning. Provide end-to-end support of IRT/RTSM implementation and lifecycle management, including URS development, system design and configuration, UAT, go-live readiness, drug supply and inventory transactions, and ongoing system changes, ensuring the IRT strategy supports clinical supply, study design, and operational requirements. Operational Excellence & Risk Management Help identify supply chain risks related to capacity, lead times, regulatory requirements, or geopolitical factors, and support development of mitigation plans in partn…

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