Executive Director, Commercial Analytics — Global Forecasting

Job Description The Executive Director, Commercial Analytics — Global Forecasting will lead the integrated global forecasting capability within Global Commercial Strategy. Reporting to the Vice President, Global Commercial Analytics, this leader will be accountable for the quality, consistency, and strategic use of forecasts across the broad Vertex portfolio, spanning early pipeline, pre-launch, launch, lifecycle, and in-line products. This is a senior enterprise leadership role with responsibility for establishing forecasting standards, governance, methodologies, and talent across the organization. The Executive Director will be a key owner of the annual Long-Range Planning (LRP) process, working closely with the Senior Vice President, Global Commercial Strategy, Corporate Finance, disease leaders, regions, and Manufacturing and Supply Chain to produce an integrated global revenue outlook and translate it into portfolio, investment, and supply-planning implications. Key Duties & Responsibilities Lead the Global Forecasting organization and capability agenda across pipeline, pre-launch, launch, lifecycle, and in-line disease areas. Own the integrated global revenue outlook for the Vertex portfolio, including underlying market, patient, access, competitive, clinical, regulatory, pricing, and commercial assumptions. Co-lead the annual LRP revenue forecasting process with GCS leadership and Corporate Finance, establishing the process, calendar, deliverables, governance, and executive decision points. Integrate disease-area forecasts into a coherent portfolio view and clearly communicate value drivers, sensitivities, risks, opportunities, uncertainties, and implications for investment. Establish enterprise forecasting standards, including model architecture, assumptions, scenario frameworks, documentation, quality control, version management, review expectations, and approval governance. Create a connected forecasting model across global and regional processes, ensuring near-term in-line forecasts and longer-range global forecasts use aligned assumptions, transparent transitions, and clearly defined accountabilities. Partner with Manufacturing and Supply Chain to translate commercial forecasts into demand and capacity-planning inputs, including appropriate scenarios, ranges, timing, and updates at material inflection points. Ensure forecasts are refreshed when material clinical, regulatory, competitive, access, market, or supply information changes the outlook or the decisions the forecast must support. Build base, upside, downside, and alternative scenarios that quantify key uncertainties and enable strategic, portfolio, launch, capital-allocation, and supply decisions. Ensure forecasts integrate evidence from Market Research, Decision Science, Competitive Intelligence, epidemiology, HEOR, Value & Access, Medical, Development, and external data sources. Provide objective forecasting leadership to disease teams and senior governance forums, pressure-testing assumptions and translating complex outputs into clear recommendations. Establish fit-for-purpose forecasting approaches across different lifecycle stages, from early opportunity assessments and commercial due diligence through launch and mature in-line products. Build scalable forecasting tools, templates, data structures, and reporting mechanisms that improve transparency, comparability, agility, and reuse across the portfolio. Select and manage external forecasting partners where specialized capacity is needed while maintaining internal ownership of methodologies, assumptions, interpretation, and quality. Build, develop, and retain a high-performing global forecasting team with strong technical depth, portfolio perspective, business judgment, and executive communication capability. Measure forecast performance, process effectiveness, stakeholder confidence, and decision impact; use lessons learned to continuously improve models, standards, and ways of working. Required…

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