Executive Director, Clinical Supply Chain

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide. Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients. The Opportunity: The Executive Director, Clinical Supply Chain provides strategic leadership and operational oversight for end-to-end clinical supply chain activities across the organization. Strategic Leadership Define and execute the global clinical supply chain strategy aligned with the company’s clinical development pipeline and long-term business goals. Establishes strategies and processes to ensure uninterrupted supply for Revolution Medicines portfolio across all phases of development. Lead and serve as subject matter expert for clinical supply chain planning, risk management, and execution of clinical supply chain activities. Build scalable processes and infrastructure to support early- through late-phase clinical programs. Strategic Planning on comparator sourcing management to ensure timely, compliant and cost-effective product availability. Effective management of clinical studies executed in conjunction with collaboration partners. Identify and implement overall clinical supply chain best practices. Clinical Supply Operations Oversee end-to-end clinical supply activities, including demand forecasting, protocol reviews, packaging, labeling, distribution, and returns. Ensure uninterrupted supply of investigational medicinal products (IMP), including RevMed and comparator products. Champions monthly Development Operations planning (DnOP) process in collaboration with PDM and Clinical Operation team members. Ensures efficient global clinical supply chain distribution networks are in place. Oversee comparator products demand and supply planning with expert level knowledge in comparator drugs and co-medications sourcing strategy Cross-Functional Collaboration Partner with Clinical Operations and Clinical Study Execution Teams (CSET) in study planning and execution. Collaborate with PDM, Quality, and Regulatory to ensure compliant manufacturing, labeling, and distribution Work closely with Finance on budgeting, forecasting, and cost optimization. Work effectively with internal and external partners to develop sound strategies, identify and mitigate risks, and resolve issues as they arise. Compliance & Quality Ensure all clinical supply activities comply with GxP, ICH, FDA, EMA, and global regulatory requirements. Expert knowledge of applicable GxP requirements and applicable regulatory guidances. Lead inspection readiness activities as required for global filings and maintain and inspection ready organization. Team Leadership Build, lead, and mentor a high-performing clinical supply chain organization. Drives for excellence in execution of agreed upon strategies. Establish clear performance metrics, development plans, and succession planning. Foster a culture of accountability, continuous improvement, and collaboration. Drives excellence in setting clear and actionable team goals. Required Skills, Experience and Education: Bachelor’s degree in Supply Chain, Business, Engineering or Life Sciences with 20+ years of experience in pharmaceutical supply chain. Master’s degree (MS, MBA) with at least 18 years of experience in pharmaceutical/biotech supply chain. CPIM/CSCP certifications a plus. At least 5 years of experience in a leadership/…

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